The integrity of a healthy skin barrier depends on lipids, sometimes referred to as "The Big Three". These lipids are ceramides (about 50% by weight), sterols (about 25% by weight), and free fatty acids (about 10-20% by weight). In the stratum corneum precursor lipids are converted to ceramides and fatty acids. Polyunsaturated fatty acids (PUFA) are precursors for these Big Three bioactive lipids.
All ceramides are based on sphingoid base. Cer-AP is a very polar and short chain N-(alpha-hydroxy acyl)-phytosphingosine ceramide. Research indicates that small, around 4-7% of this ceramics type is found in the stratum corneum.
Our blend of ceramides mimics what is already in your skin and suits everyone including those with sensitive skin.
- Restore the toll on skin from aging or environmental pollution
- Improve skin tone and texture
- Keep the outer most layer of the epidermis, the stratum corneum, intact
- Protects transepidermal water loss (TEWL)
Farwanah, Hany, et al. "Ceramide profiles of the uninvolved skin in atopic dermatitis and psoriasis are comparable to those of healthy skin." Archives of dermatological research 296.11 (2005): 514-521.
Jennemann, Richard, et al. "Loss of ceramide synthase 3 causes lethal skin barrier disruption." Human molecular genetics 21.3 (2012): 586-608.
Persikov, A. V., et al. "Changes in the ceramide profile of atopic dermatitis patients." J Invest Dermatol 130 (2010): 2511-4.
Sahle, Fitsum F., et al. "Development and validation of LC/ESI-MS method for the detection and quantification of exogenous ceramide NP in stratum corneum and other layers of the skin." Journal of pharmaceutical and biomedical analysis 60 (2012): 7-13.